
Although also of the majority party, the curmudgeonly president pro tempore Seabright "Seab" Cooley of South Carolina dislikes Leffingwell for both personal and professional reasons and leads the opposition. Demagogic peace advocate Fred Van Ackerman of Wyoming is especially supportive, but Munson repeatedly advises him not to aggravate the situation.

Senate Majority Leader Bob Munson, the senior senator from Michigan, loyally supports the nominee despite his doubts, as do the hard-working majority whip Stanley Danta of Connecticut and womanizer Lafe Smith of Rhode Island. The parties of both the president and the minority are divided. Leffingwell's nomination is controversial within the Senate, which must use its advice and consent powers to approve or reject the appointment. The second-term president, who is ill, has chosen him in part because he does not believe that Vice President Harley Hudson, whom both he and others usually ignore, will successfully continue the administration's foreign policy should the president die. The film, set in Washington, D.C., follows the nomination process of a man who commits perjury in confirmation hearings for his nomination as Secretary of State. 2, which provides that the president of the United States "shall nominate, and by and with the Advice and Consent of the Senate, shall appoint Ambassadors, other public Ministers and Consuls, Judges of the Supreme Court, and all other Officers of the United States." The title derives from the United States Constitution's Article II, Sec. The ensemble cast features Henry Fonda, Charles Laughton, Don Murray, Walter Pidgeon, Peter Lawford, Gene Tierney, Franchot Tone, Lew Ayres, Burgess Meredith, Eddie Hodges, Paul Ford, George Grizzard, Inga Swenson, Betty White and others.

The film was adapted for the screen by Wendell Mayes and was directed by Otto Preminger. Advise & Consent is a 1962 American political drama film based on the Pulitzer Prize–winning novel Advise and Consent by Allen Drury, published in 1959.
